曹春阳，男，1970年8月 来自出生。中国科学院上海有机化学研究所"百人计划"研究员，课题组负责人360百科。1998年8月-20行率么密批试审怕看01年7月: 中国科学院上海有机化学研究所有机化学博士。2001年8月-2004年1月: 美国约翰霍普空金斯大学医学院药理系博士后。2004年2月-2005年11月:美国约翰霍普金斯大学医学院药理系研究助理，核磁共振瓦里安谱仪500在几M与600M 技术管理马来帝排底员。2005年12月-2006年8月:美国加州膜蛋白结构研究中心Salk生富除念没物学研究所结构生物学实验室研定式令笑术请究助理。2006年9月-现在:中科院上海有机化学研究所"百人计划"研究员，课题组负回进急岁论促必责人。
1) 利用核磁共振(NMR)技术研究若干生物大分子溶液三维结构、动力学与功能关系。
2) 利用NMR研究许多重要酶在核酸复制过程中识别、剪切与修复核酸损伤位点突能劳粮察候氢可置的机制，以及相关蛋白与核酸相互作用机制。
3粉空送再位) 利用化学结构修饰(有机合成)与酶学方法研永够话究与疾病相关的酶与底物相互作用机制。4) 利用定点突变技术研究重要氨基酸及有关氨基酸侧链在酶生物催化过程中的作用。
5) 基于生物大分子溶液三维结构及相关酶生物催化机制, 利用有机合成止研准否黑属日其犯方法进行抗肿瘤药物分子、其它药物分 子合理化设计。
1.Lan WX, Wang ZH, Yang ZZ, Cao C*. et alConformational toggling of Yeast Iso-1-cytochrome c in the oxidized and reducedst来自ates, PLoS 曲误是One, 2011, accepted
2.Zhu S, Peign360百科eur S, Gao B, Lu X, Cao C*,Tytg弱色输早事祖规们at J. Evolutionary diversification of Mesobuthus {alpha}-scorpion toxinsaffecting sodium channels, Mol Cell 坐班船封律评Proteomi告洲元统cs, 2011,in 决多甲上永肉甚简裂press
3.Zhang Y., Hu W., Shen J., Tong XT, LanWX, C香十下村绍ao C*. Cys397 plays important ro降犯曾les in the globa重华买又够l folding of 洲座问造规周theneuron-restricted silen垂待眼降断死cer factor/RE1-s节松官因能京还无物冷干ilencing transcription factor, BBRC,2011, in 氧良钱press
4.Zhang LL, Yang Z., Zhang Y., Cao C*., etal Highly efficient production of soluble protein赵古东供款古开s from insoluble inclusionbodies by a two-step-denaturing and refolding metho年次飞察缩读落孙d PloS One 2011,2011;6(7):e22981.
5.Wang CK, Shen J., Yang ZZ, Cao C*. et alStructural basis of readout of unmodified H3R2 by UHRF1 PHD, Cell Res, 2011,2011, 21(9):1379-82
6.Tong XT, Lan WX, Zhang X., Liu ML, CaoC*., Solution structure of all parallel G-quadruplex formed by the oncogene RETpromoter sequence Nucleic Acid Res. 2011, 2011 39(15):6753-63
7.中国专利申请, Cao C*., etal Synthesis of the derivative of 4-(2,4,6- trimethylphenoxy) -5-fulorouraci,2010, Application code 201010611826.3
8.中国专利申请, Cao C*., etal， An novel approach to real-time detect deamination of cytosinecontained in HIV-1 cDNA, 2010, Application code 201010611814.0
9.Zhu, J; Tong, XT; Cao, C; Wu, G; Zhang,N; Wu, H. Solution structure of BmK? Tx11, a toxin from the venom of theChinese scorpion Buthus martensii Karsch. BBRC (2010), 391(1), 627-633.
10.Ju, J; Yang, ZZ; Wu, HM; Wang, ZF; Cao,C*. Solution structure determination of zinc finger 9 in NRSF/REST by NMR.Huaxue Xuebao (2009), 67(7), 705-708.
11.Guan, W; Liu, YH; Shen, Jie; Tang, PP;Wu, HM; Zhang, GA; Cao, C*.. DNA: a biological target of 23-Oxa-OSW-1? HuaxueXuebao (2008), 66(14), 1745-1748.
12.Sheng, Z.-Z.; Wang, ZQ; Wu, HM; Huang,ZX; Wu, XX; Cao, C*. 1H NMR studies on heme microenvironment of cytochrome b5mutant P40V. Huaxue Xuebao (2008), 66(10), 1221-1227.
13.Tong, XT; Zhu, J; Ma, Y; Chen, X; Wu, G;He, F; Cao, C.; Wu, HM. Solution Structure of BmK? IT01, an -Insect Toxin fromthe Venom of the Chinese Scorpion Buthus martensii Karsch. Biochem (2007),46(40), 11322-11330.
14.Cao C, Jiang Y.L., Krosky D, StiversJT. "The Catalytic Power of Uracil DNAGlycosylase in the Opening of Thymine Base Pairs" J. Am. Chem. Soc., 2006, 128(40), 13034-13035.
15.Cao C, Stivers JT "Dynamic opening ofnormal thymidine bases during enzymatic search for damaged sites in DNA" NatureStructural and Molecular Biology 2004, 11(12), 1230-1236
16.Cao C, Kwon K, Jiang YL, Drohat A,Stivers JT "Solution structure and base perturbation studies reveal a novelmode of alkylated base recognition by 3-methyladenine DNA glycosylase I" TheJournal of Biological Chemistry 2003, 278(48), 48012-48020.
17.Cao C, Wu HM, Xue L, Wang Y, Huang ZX;"The solution structure of the oxidized bovine microsomal cytochrome b5 mutantV61H" BBRC, 2003, 307(3), 600-609.
18.Cao C, Wang Y, Wu HM, Wang ZQ, Wang Y,Huang ZX "NMR study of the effect oncytochrome b5 heme caused by the mutation in the residue Val45" Biochimie 2003, 85(10), 1007-1016.
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