钟大放，中国科学院上海药物研究所研究员。
1982 年毕业于沈阳药学院化约军用随学制药专业，
1985 年获药物分析专业硕士学位，
1989 年在联邦德国波恩大学获药物化学专业博士学位，来自其后在德国药师中心实验室 从事 博士后研究。
1994 年 7 月回国，历任沈阳药科大学教授、博士生导师、药物代谢与药物动力学实验化黑复景状将日曲室主任。
1996 年获国家杰出青年科学基金。
2005 年 6 月起任中国科学360百科院上海药物研究所研究员、药物代谢研究中心主任。
承担科研项目情况: |
曾主持国家自然科学基金重点项目和国家"863"项目等课题，为国内制药企业完成新药代谢和药动学临床前研究 20 余项，为国内外制药企业完成药物动力学和制剂生物等效性试验300余项。现承担科研课题有国家自然科学基金、国家 863 课题、上海市科委研发公共服务平台"上海药物代谢研究中心"建设项目，以及为国内陈翻待被耐日完某号给并外制药企业和研究院所提供药物代头销圆酒划谢研究技术服务。 |
Liu J, Chen XY, Liu K, Li L, Zhong DF*. Derivatizat苗章头书术圆贵跑ion of (5R)-h化手料掉们补困易全药ydroxytriptolide with benzylamine to enhance mass spectrometric detection: Applica威帮后曾球美tion to a Phase I p出harmacokinetic studie. Analytica Chimica Acta, 2011, 689: 69-76
Li L, Chen XY, Li D否逐主, Zhong DF*死接护. Identification of 20(S)-protopanaxad贵十硫iol metabolite胞排击选护钢缺s in human liver microsomes and human hepat端ocytes. Drug Me供达均刻tabolism an念责优外敌斯d Disposition, 2011, 39: 472-483
Deng P, You TG, Chen XY, Yuan T, Huang HH, Zhong DF*. Identification of a眼陆剧官测识事棉季讲miodarone metabolites in human bile by ultraperforman措袁些都音马足弱江需药ce liquid chroma罪转末志施罪顶话宗责称tography/quadrupole time-of-flight mass spectrometry. Drug Metabolism and Disposition, 2011, 39: 1058-1069
Gao CY, Chen XY, Zhong DF*. Absorption and disposition of scutellarin in rats: a pharmacokinetic explanation for the high exposure of its isomeric metabolite. Drug Metabolism and Disposition, 2011, 39: 2034-2044
Zhong DF. Bioanalysis in China. Bioanalysis, 2010, 2: 153-156
Gong Aishen, Chen XY, Deng P, Zhong DF*. Metabolism of flumatinib, a novel antineoplastic tyrosine kinase inhibitor, in chronic myelogenous leukemia patients. Drug Metabolism and Disposition, 2010, 38: 1328-1340
Tan B, Zhang YF, Chen XY, Zhao XH, Li GX, Zhong DF*. The effects of CYP2C9 and CYP2C19 genetic polymorphisms on the pharmacokinetics and pharmacodynamics of glipizide in Chinese subjects. European Journal of Clinical Pharmacology, 2010, 66: 145-151
Liu J, Chen XY, Hu YH, Cheng G, Zhong DF*. Quantification of the major metabolites of bromhexine in human plasma using RRLC-MS/MS and its application to pharmacokinetics. Journal of Pharmaceutical and Biochemical Analysis, 2010, 51: 1134-1141
Deng P, Chen XY, Zhang GD, Zhong DF*. Bioanalysis of an oligonucleotide and its metabolites by liquid chromatography-tandem mass spectrometry. Journal of Pharmaceutical and Biochemical Analysis, 2010, 52: 571-579
Deng P, Chen XY, Zhong DF*. Quantification of polar drugs in human plasma with LC-MS/MS. Bioanalysis, 2009, 1: 187-203
Liu J, Duan XT, Chen XY, Zhong DF*. Determination of eptifibatide concentration in human plasma utilizing the liquid chromatography–tandem mass spectrometry method. Journal of Chromatography B, 2009, 877: 527-532
Zhan Y, Chen XY, Zhao XH, Zhong DF*. Rapid and sensitive liquid chromatography-tandem mass spectrometry method for the determination of leuprolide in human serum. Journal of Chromatography B, 2009, 877: 3194-3200
Meng J, Zhao LZ, Hu YH, Chen XY, Zhong DF*. Synthesis of [3-3H]20(S)-protopanaxadiol. Journal of Labelled Compounds and Radiopharmaceuticals, 2009, 52: 482-484
Wang YY, Chen XY, Li Q, Zhong DF*. Metabolite identification of arbidol in human urine by the study of CID fragmentation pathways using HPLC coupled with ion trap mass spectrometry. Journal of Mass Spectrometry, 2008, 43: 1099-1109
Wang YY, Chen XY, Li Q, Zhong DF*. Characterization of metabolites of a novel histamine H2-receptor antagonist, lafutidine, in human liver microsomes by liquid chromatography coupled with ion trap mass spectrometry. Rapid Communications in Mass Spectrometry, 2008, 22: 1843-1852
Guan ZM, Chen XY, Wang YX, Zhong DF*. Metabolite identification of a new antitumor agent icotinib in rats using liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 2008, 22: 2176-2184
Zhang YF, Si DY, Chen XY, Lin N, Guo YJ, Zhou H, Zhong DF*. Influence of CYP2C9 and CYP2C19 genetic polymorphisms on pharmacokinetics of gliclazide MR in Chinese subjects. British Journal of Clinical Pharmacology, 2007, 64: 67-74
Li XY, Chen XY, Zhong DF*. Validated method for rapid inhibition screening of six cytochrome P450 enzymes by liquid chromatography-tandem mass spectrometry. Journal of Chromatography B, 2007, 852: 128-137
Duan XT, Chen XY, Yang YM, Zhong DF*. Precolumn derivatization of cysteine residues for quantitative analysis of five major cytochrome P450 isoenzymes by liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 2007, 21: 3234-3244
Huang HH, Yang XW, Li Qiang, Sun L, Zhong DF*. Biotransformation of tolbutamide to 4'-tolbutamide by the fungus Cunninghamella blakesleeana. Applied Microbiology and Biotechnology, 2006, 72: 486-491
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