王祯莲

王祯莲，女，1999年9月-2004年6月 山西医科大学临床医学 医学学士

2004年9月-2007年6月 中南大学湘雅医学院肿瘤研究所 医学硕士

• 中文名称 王祯莲
• 国籍 中国
• 民族 汉族
• 性别 女

工作经历:

　　2来自007年7月-2012年9月温州医学院眼视光学院

　　2012年11月-至今常州大学制药与生命科学学院

研究方向:

　　1.HGF360百科/c-Met在葡萄膜黑色素瘤侵袭和转移中的分子机制研究。

　　2.GPR48基因在眼睑发育中的作用和机制研究。

承担科研项目情况:

　　1.主持国家自然科学基金青年基金(No.8土术概1201657)"HGF/c-Met促进葡萄膜黑色素瘤侵袭和转移的分子机制研究"(2013.01-2015.12)

　　劳带2.主持浙江省自然科学基金(No. Y2100280)"G蛋白偶联受体48基因调节眼睑发育的分子机制研究"(2010.06-2012.06)

　　3.主持温州市科技计划项目(No. Y20090098)"Gpr48激活EGFR调节ERK1/2来自和STAT3信号通路促进眼睑上皮发育的分子机制研究"(20轮称洲站普着设09.06-20波兴意般采认双固供技12.12)

科研成果:

　　普色1.Zhenlian Wang*,Chang Jin*, Hongxia Li, Ca360百科nxia Li, Qiang Hou, Mingyao Liu, Xiangd名倒足景带a Dong, Lili Tu.GPR48-Induced Keratinocyte Proliferat太是乡机国际功庆接划ion Occurs through HB-EGF Mediated EGFR tra范效便针讲免句临号远差nsactiva既菜全照卷tion. FEBS Letters.2010 Sep 24; 584(18):4057-4062.(* Equal-contribution first author)

　　2.Zhenlian Wang*,Feijun Luo*, Lili Li*, Lifang Yang, Duosha Hu, Xiaoqian Ma, Zhongxin L数参跟么字稳士念刻急传u, Lunquan Sun移雷是船免似星皇质, Ya Cao. STAT3 activation induced b具记细失践致防向期步染y Epstein-Barr virus latent membrane protein1 causes vascular endothelial growth factor expression and cell担ular invasiveness via JAK3 and ERK signaling.Eur J Cancer. 2010 Nov; 46(16):2996-3006.(* Equal-contribution first author)

　　3.Chang 铁实第劳针差Jin, Furong Yin, Mimi Lin, Hongxia Li, Zhenlian Wang, Ji凯袁别严通读比队兴nsheng Wen, Mingyao Liu, Xiangda Dong, Jia Qu, Lili Tu.. GPR48 regulates epithelial cell proliferation and migration by activating EGFR during eyelid development. Invest Ophthalmol Vis Sci. 2008 Oct; 49(10):4245-4253.

　　4.Haidan Liu, Hui Zheng, Zhi Duan, Du吗派年挥围注举刘娘声情osha Hu, Min Liu, Sufang Liu, Zijian Liu, Xiyun Deng, Zhenlian Wang, Min tang, Yin Shi, Wei Yi, Ya Ca投帝磁o.LMP1-augmented kappa i留许才简整ntron enhancer activity contributes to upregulation expression of Ig kappa light chain via NF-kappaB and AP-1 pathways in nasopharyngeal carcinoma cells.Mol Cancer. 2009 Oct 27;8:92.

　　5.Wei Luo, Guangrong Yan, Lili Li, Zhenlian Wang, Haidan Liu, Shanghui Zhou, Sufang Liu, Min Tang, Wei Yi, Zigang Dong, Ya Cao. Epstein-Barr virus latent membrane protein 1 mediates serine 25 phosphorylation and nuclear entry of annexin A2 via PI-PLC-PKCalpha/PKCbeta pathway. Mol Carcinog. 2008 Dec;47(12):934-46.

　　6.Zhongxin Lu, Xiaoqian Ma, Lifang Yang , Zhenlian Wang, Liang Zeng, Zijiang Li, Min Tang, Wei Yi, Ya Cao. DNAzymes targeted to EBV-encoded latent membrane protein-1 induce apoptosis and enhance radiosensitivity in nasopharyngeal carcinoma. Cancer Lett. 2008 Jul 8;265(2):226-238.

　　7.Yiping Liu, Yunnian Tan, Zhenliang Wang, Liang Zeng, Zhongxin Lu, Lili Li, Wei Luo, Min Tang, Ya Cao. Phosphorylation and nuclear translocation of STAT3 regulated by LMP1 in nasopharyngeal carcinoma. Int J Mol Med. 2008 Feb;21(2):153-162.

　　8.Lili Li, Lili Guo, Yongguang Tao, Shanghui Zhou, Zhenlian Wang, Wei Luo, Duosha Hu, Zijian Li, Min Tang, Wei Yi, Tsao SW, Ya Cao. Latent membrane protein 1 of Epstein-Barr virus regulates p53 phosphorylation through MAP kinases. Cancer Lett. 2007 Oct 8;255(2):219-231.

　　9.Xin Jin, Xin Song, Lili Li, Zhenlian Wang, Yongguang Tao, Ling Deng, Min Tang, Wei Yi, Ya Cao. Blockade of AP-1 activity by dominant-negative TAM67 can abrogate the oncogenic phenotype in latent membrane protein 1-positive human nasopharyngeal carcinoma. Mol Carcinog. 2007 Nov;46(11):901-911.